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![]() In addition, Omicron as a “COVID-21” pandemic means we should reconsider the future of SARS-CoV-2 in terms of what to anticipate and how to recognize what actions to take. In my opinion, this concept that the SARS-CoV-2 Omicron variant of concern is already becoming the second SARS-CoV-2 pandemic, a “COVID-21,” is crucial because it means we will need to reexamine our responses to Omicron. Influenza A virus antigenic shifts require new pandemic influenza-specific vaccines. Mutations in the immunodominant hemagglutinin (H) protein of influenza cause major antigenic changes termed “antigenic shift” (rather than lesser, more frequent changes termed “antigenic drift”). With influenza, an antigenic shift is a hallmark of a new influenza pandemic. Of note, these authors do not propose that Omicron will become a second pandemic, despite their use of the term “Omicron antigenic shift.” While influenza antigenic shift is defined as genetic reassortment of the RNA genome segments, the mechanism of accumulation of a large number of mutations in SARS-CoV-2 Omicron S remains to be established.” “The staggering number of substitutions present in Omicron S marks a dramatic shift in antigenicity and is associated with immune evasion of unprecedented magnitude for SARS-CoV-2 and a putative broadening of tropism. 14, an international group of renowned researchers posted a manuscript on bioRxiv titled, “Broadly neutralizing antibodies overcome Omicron antigenic shift.” They state: Lucey, MD, MPH, FIDSA Facebook Twitter LinkedIn Email ![]() Medical Education Community of Practiceĭaniel R.Fellows-In-Training Career & Education Center.myIDSA Practice Managers Community Opt-in Form.Antimicrobial Stewardship Centers of Excellence Program.
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